C3a receptor (C3a anaphylatoxin chemotactic receptor) is a receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. The receptor is widely expressed in many hematopoietic cell lines, throughout the CNS and other tissues, and the expression level in glial cells increases during CNS inflammation. It stimulates chemotaxis, granule enzyme release and superoxide anion production,mediates the pathogenesis of demyelinating disease by directly or indirectly chemoattracting encephalitogenic cells to the CNS. Administration of small molecule inhibitors of C3a receptor inhibits airway responses.
s://creative-bioarray/acroscell/human-c3ar1-gi-go-stable-cell-line-cho-acc-rg0573-item-373
